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Fentanyl is a potent, synthetic opioid pain medication with a quick onset and short duration of action. Fentanyl is 70 to 110 times more potent than morphine, but some fentanyl analogs, which are designed to resemble the pharmacological effects of the original drug, maybe as much as 9,999 times more potent than morphine. buy fentanyl patches online without a prescription. Paul Janssen 1960 made the first fentanyl following the medical inception of Demerol several years earlier.
The widespread use of fentanyl triggered the production of fentanyl citrate which entered medical use as a general anesthetic under the trade name Sublimaze in the 1960s. In the 1990s, fentanyl was introduced for pain relief use with the fentanyl patch, followed in the next decade by the introduction of the fentanyl lollipop, dissolving tablets, and sublingual sprays which are absorbed through the tissues inside the mouth. Since 2012, fentanyl is the most widely used synthetic opioid in medicine and 1700 kilograms is consumed globally. Fentanyl is also used as a recreational drug, leading to thousands of overdose deaths from 2000 to 2017.
Intravenous fentanyl is often used for anesthesia(used along with propofol) and pain relieving. It is often used in the management of chronic pain including cancer pain. It is also administered in combination with a benzodiazepine, such as midazolam, to produce sedation for procedures such as endoscopy, cardiac catheterization, and oral surgery.
Fentanyl transdermal patches (Duragesic) are used in chronic pain management. The patches work by slowly releasing fentanyl through the skin into the bloodstream over 48 to 72 hours, allowing for long-lasting pain management. Dosage is based on the size of the patch, since, in general, the transdermal absorption rate is constant at a constant skin temperature. The rate of absorption is dependent on a number of factors.
Body temperature, buying fentanyl online skin type, amount of body fat, and placement of the patch can have major effects. The different delivery systems used by different makers will also affect individual rates of absorption. Under normal circumstances, the patch will reach its full effect within 12 to 24 hours; thus, fentanyl patches are often prescribed with a fast-acting opiate (such as morphine or oxycodone) to handle breakthrough pain. It is unclear if fentanyl gives pain relief to people with neuropathic pain. Buy fentanyl patches online
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